In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
نویسندگان
چکیده
منابع مشابه
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.
Mitochondrial dysfunction is implicated in aging and degenerative disorders such as Parkinson's disease (PD). Continuous fission and fusion of mitochondria shapes their morphology and is essential to maintain oxidative phosphorylation. Loss-of-function mutations in PTEN-induced kinase1 (PINK1) or Parkin cause a recessive form of PD and have been linked to altered regulation of mitochondrial dyn...
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Dopamine neurons of the ventral midbrain have been found to signal a reward prediction error that can mediate positive reinforcement. Despite the demonstration of modest diversity at the cellular and molecular levels, there has been little analysis of response diversity in behaving animals. Here we examine response diversity in rhesus macaques to appetitive, aversive, and neutral stimuli having...
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Dopaminergic midbrain neurons are involved in many important brain functions including motor control, as well as emotive and cognitive tasks. They also play critical roles in major disorders likes Parkinson disease, schizophrenia, drug abuse and attention-deficit hyperactivity disorder. This bewildering diversity of distinct dopaminergic functions appears to be in contrast to the routinely assu...
متن کاملNeurobiology of Disease Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons
Amandine Berthet,1 Elyssa B. Margolis,2 Jue Zhang,1 Ivy Hsieh,6 X Jiasheng Zhang,6 Thomas S. Hnasko,4 Jawad Ahmad,1 Robert H. Edwards,2,3 Hiromi Sesaki,5 Eric J. Huang,3,6 and Ken Nakamura1,2,3 1Gladstone Institute of Neurological Disease, San Francisco, California 94158, 2Department of Neurology and 3Graduate Programs in Neuroscience and Biomedical Sciences, University of California, San Franc...
متن کاملLoss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.
Disruptions in mitochondrial dynamics may contribute to the selective degeneration of dopamine (DA) neurons in Parkinson's disease (PD). However, little is known about the normal functions of mitochondrial dynamics in these neurons, especially in axons where degeneration begins, and this makes it difficult to understand the disease process. To study one aspect of mitochondrial dynamics-mitochon...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.48408